A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID:
MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]]; Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]; Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA]; empagliflozin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Lithium inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; nardosinone inhibits the reaction [Rotenone results in increased expression of SNCA protein]; nootkatone inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Roflumilast inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]; Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein; Rotenone results in increased phosphorylation of and results in increased expression of SNCA protein; SNCA protein promotes the reaction [Rotenone results in decreased abundance of Dopamine]; SNCA protein promotes the reaction [Rotenone results in decreased expression of TH protein]; Valproic Acid inhibits the reaction [Rotenone affects the localization of SNCA protein modified form]; Valproic Acid inhibits the reaction [Rotenone results in increased ubiquitination of SNCA protein]; vinpocetine inhibits the reaction [Rotenone results in increased expression of SNCA protein]; YWHAE mutant form promotes the reaction [Rotenone results in increased expression of SNCA protein]
SNCA gene mutant form results in increased susceptibility to Rotenone; SNCA protein mutant form results in increased susceptibility to Rotenone; SNCA protein results in increased susceptibility to Rotenone
3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]; [1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine co-treated with Rotenone] results in increased expression of SNCA protein; [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein]; alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein]; geraniol inhibits the reaction [Rotenone results in increased expression of SNCA protein]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to YWHAB protein]; SIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; SNCA protein promotes the reaction [Rotenone results in increased secretion of CASP3 protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; TRAP1 protein inhibits the reaction [SNCA protein affects the susceptibility to Rotenone]; ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]
4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; [bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; carbidopa, levodopa drug combination inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Niacin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; PANK1 mRNA alternative form affects the reaction [Rotenone results in increased expression of SNCA mRNA]; PANK1 mRNA alternative form affects the reaction [Rotenone results in increased expression of SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB3A protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB5A protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB8A protein]; Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein; Rotenone results in increased secretion of and results in increased uptake of and affects the localization of SNCA protein; SESN2 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; ZM 241385 inhibits the reaction [Rotenone results in increased expression of SNCA protein]