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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaaffects localizationEXP 6480464CTDRotenone affects the localization of SNCA protein; Rotenone affects the localization of SNCA protein modified formPMID:11100151 PMID:17690729 PMID:19626387
Sncadecreases degradationEXP 6480464CTDRotenone results in decreased degradation of SNCA proteinPMID:25433145
Sncadecreases expressionEXP 6480464CTDRotenone results in decreased expression of SNCA proteinPMID:25430725
Sncaincreases expressionEXP 6480464CTDRotenone results in increased expression of SNCA mRNA; Rotenone results in increased expression of SNCA proteinPMID:16219024 PMID:16439141 PMID:18289173 PMID:24002177 PMID:28389404 PMID:28585189 PMID:31022188 PMID:35654124 PMID:35728354 PMID:35833337 PMID:36965781 PMID:37105514
Sncaincreases phosphorylationEXP 6480464CTDRotenone results in increased phosphorylation of SNCA proteinPMID:37224993
Sncaincreases response to substanceEXP 6480464CTDSNCA protein results in increased susceptibility to RotenonePMID:26075822
Sncaincreases ubiquitinationEXP 6480464CTDRotenone results in increased ubiquitination of SNCA proteinPMID:19626387
Sncamultiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]]; Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]; Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA]; empagliflozin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Lithium inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; nardosinone inhibits the reaction [Rotenone results in increased expression of SNCA protein]; nootkatone inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Roflumilast inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]; Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein; Rotenone results in increased phosphorylation of and results in increased expression of SNCA protein; SNCA protein promotes the reaction [Rotenone results in decreased abundance of Dopamine]; SNCA protein promotes the reaction [Rotenone results in decreased expression of TH protein]; Valproic Acid inhibits the reaction [Rotenone affects the localization of SNCA protein modified form]; Valproic Acid inhibits the reaction [Rotenone results in increased ubiquitination of SNCA protein]; vinpocetine inhibits the reaction [Rotenone results in increased expression of SNCA protein]; YWHAE mutant form promotes the reaction [Rotenone results in increased expression of SNCA protein]PMID:18289173 PMID:19626387 PMID:24002177 PMID:25433145 PMID:26075822 PMID:28389404 PMID:28585189 PMID:29649621 PMID:35654124 PMID:35728354 PMID:35833337 PMID:36965781 PMID:37105514 PMID:37224993
Sncaaffects localizationISOSNCA (Homo sapiens)6480464CTDRotenone affects the localization of SNCA protein; Rotenone affects the localization of SNCA protein mutant formPMID:19628769
Sncaaffects localizationISOSnca (Mus musculus)6480464CTDRotenone affects the localization of SNCA proteinPMID:20464527
Sncaaffects response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA protein affects the susceptibility to RotenonePMID:22319455 PMID:27585560
Sncadecreases expressionISOSNCA (Homo sapiens)6480464CTDRotenone results in decreased expression of SNCA mRNA; Rotenone results in decreased expression of SNCA proteinPMID:27133439
Sncadecreases response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA protein results in decreased susceptibility to RotenonePMID:16239214 PMID:17041725
Sncadecreases ubiquitinationISOSNCA (Homo sapiens)6480464CTDRotenone results in decreased ubiquitination of SNCA protein modified formPMID:33157086
Sncaincreases expressionISOSNCA (Homo sapiens)6480464CTDRotenone results in increased expression of SNCA mRNA alternative form; Rotenone results in increased expression of SNCA proteinPMID:12177198 PMID:15114628 PMID:15280438 PMID:16439141 PMID:17131421 PMID:19114014 PMID:19857570 PMID:20414966 PMID:23535362 PMID:23984410 PMID:27053302 PMID:30141137 PMID:30408497
Sncaincreases expressionISOSnca (Mus musculus)6480464CTDRotenone results in increased expression of SNCA mRNA; Rotenone results in increased expression of SNCA proteinPMID:17459145 PMID:26031332 PMID:27425033 PMID:30769001 PMID:31820278 PMID:35589691
Sncaincreases phosphorylationISOSNCA (Homo sapiens)6480464CTDRotenone results in increased phosphorylation of SNCA proteinPMID:33157086
Sncaincreases phosphorylationISOSnca (Mus musculus)6480464CTDRotenone results in increased phosphorylation of SNCA proteinPMID:33157086 PMID:36048341
Sncaincreases response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA gene mutant form results in increased susceptibility to Rotenone; SNCA protein mutant form results in increased susceptibility to Rotenone; SNCA protein results in increased susceptibility to RotenonePMID:12151787 PMID:18514418 PMID:23153578 PMID:24290359 PMID:26963176
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTD3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]; [1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine co-treated with Rotenone] results in increased expression of SNCA protein; [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein]; alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein]; geraniol inhibits the reaction [Rotenone results in increased expression of SNCA protein]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to YWHAB protein]; SIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; SNCA protein promotes the reaction [Rotenone results in increased secretion of CASP3 protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; TRAP1 protein inhibits the reaction [SNCA protein affects the susceptibility to Rotenone]; ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]PMID:15280438 PMID:16239214 PMID:16439141 PMID:19114014 PMID:20414966 PMID:22319455 PMID:23244436 PMID:26963176 PMID:27053302 PMID:27133439 PMID:29649621 PMID:30141137 PMID:30408497
Sncamultiple interactionsISOSnca (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; [bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; carbidopa, levodopa drug combination inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Niacin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; PANK1 mRNA alternative form affects the reaction [Rotenone results in increased expression of SNCA mRNA]; PANK1 mRNA alternative form affects the reaction [Rotenone results in increased expression of SNCA protein]; Rotenone promotes the reaction [SNCA protein binds to SNCA protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB3A protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB5A protein]; Rotenone promotes the reaction [SNCA protein mutant form binds to RAB8A protein]; Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein; Rotenone results in increased secretion of and results in increased uptake of and affects the localization of SNCA protein; SESN2 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]; ZM 241385 inhibits the reaction [Rotenone results in increased expression of SNCA protein]PMID:15099020 PMID:17459145 PMID:23205266 PMID:26031332 PMID:27425033 PMID:30769001 PMID:31820278 PMID:35589691 PMID:36048341
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