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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315043 Species: Homo sapiens RGD Object: Gene Symbol: MAP3K5 Name: mitogen-activated protein kinase kinase kinase 5

Acc ID: CHEBI:28201 Term: rotenone Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). CasRN: 83-79-4 Chemical ID: MESH:D012402

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO		6480464	CTD	Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]	PMID:16449798
multiple interactions	ISO	RGD:1315044	6480464	CTD	Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]	PMID:16449798