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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1decreases expressionEXP 6480464CTDRotenone results in decreased expression of PINK1 mRNA; Rotenone results in decreased expression of PINK1 proteinPMID:32392329 PMID:36538285
Pink1increases expressionEXP 6480464CTDRotenone results in increased expression of PINK1 mRNAPMID:28374803
Pink1multiple interactionsEXP 6480464CTD[Particulate Matter co-treated with Rotenone] results in decreased expression of PINK1 protein; repaglinide inhibits the reaction [Rotenone results in decreased expression of PINK1 mRNA]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PINK1 protein]PMID:33823232 PMID:36538285
Pink1affects localizationISOPINK1 (Homo sapiens)6480464CTDRotenone affects the localization of PINK1 proteinPMID:32001317
Pink1affects response to substanceISOPINK1 (Homo sapiens)6480464CTDPINK1 protein affects the susceptibility to RotenonePMID:16226715 PMID:20940149
Pink1affects response to substanceISOPink1 (Mus musculus)6480464CTDPINK1 protein affects the susceptibility to RotenonePMID:21421046 PMID:26916954
Pink1decreases expressionISOPINK1 (Homo sapiens)6480464CTDRotenone results in decreased expression of PINK1 mRNAPMID:33512557
Pink1decreases response to substanceISOPINK1 (Homo sapiens)6480464CTDPINK1 protein results in decreased susceptibility to RotenonePMID:19492085
Pink1increases expressionISOPINK1 (Homo sapiens)6480464CTDRotenone results in increased expression of PINK1 proteinPMID:37156403
Pink1increases expressionISOPink1 (Mus musculus)6480464CTDRotenone results in increased expression of PINK1 proteinPMID:20464527
Pink1multiple interactionsISOPINK1 (Homo sapiens)6480464CTD4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased expression of PINK1 protein]; CSNK2A1 protein affects the reaction [Rotenone results in increased expression of PINK1 protein]; DNM1L protein affects the reaction [Rotenone affects the localization of PINK1 protein]; PGAM5 protein affects the reaction [Rotenone results in increased expression of PINK1 protein]; PINK1 protein affects the reaction [Rotenone results in increased cleavage of CASP3 protein]; Rotenone promotes the reaction [PRKN protein binds to PINK1 protein]PMID:32001317 PMID:37156403
Pink1multiple interactionsISOPink1 (Mus musculus)6480464CTD[Particulate Matter co-treated with Rotenone] results in decreased expression of PINK1 protein; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PINK1 protein]PMID:33823232
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