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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdkn1b Name: cyclin-dependent kinase inhibitor 1B

Acc ID: CHEBI:28177 Term: theophylline Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. CasRN: 58-55-9 Chemical ID: MESH:D013806

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69115	6480464	CTD	[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein	PMID:21693435
multiple interactions	EXP		6480464	CTD	[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]	PMID:21693435