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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkdc
Name: protein kinase, DNA-activated, catalytic subunit
Acc ID: CHEBI:2814
Term: arecoline
Definition: A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Chemical ID: MESH:D001115
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkdcdecreases expressionISOPRKDC (Homo sapiens)6480464CTDArecoline results in decreased expression of PRKDC mRNAPMID:17682004
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