• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736217 Species: Homo sapiens RGD Object: Gene Symbol: CYP2D6 Name: cytochrome P450, family 2, subfamily D, polypeptide 6

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736218	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA	PMID:17942748
increases expression	ISO	RGD:620640	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYP2D4 protein	PMID:12361703
decreases expression	ISO	RGD:736218	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CYP2D22 mRNA	PMID:19770486
decreases expression	ISO	RGD:620640	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CYP2D4 mRNA	PMID:21215274
affects expression	ISO	RGD:736218	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of CYP2D22 mRNA	PMID:21570461
decreases expression	ISO	RGD:2472	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CYP2D3 mRNA	PMID:21215274