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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735960 Species: Homo sapiens RGD Object: Gene Symbol: F2R Name: coagulation factor II (thrombin) receptor

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of F2R mRNA	PMID:12377990
affects expression	ISO	RGD:10556	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of F2R mRNA	PMID:20702594
decreases expression	ISO	RGD:10556	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of F2R mRNA	PMID:19770486
affects expression	ISO	RGD:2586	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of F2R mRNA	PMID:22298810
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of F2R mRNA	PMID:23152189