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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71039
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgll
Name: monoglyceride lipase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgllaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of MGLL mRNAPMID:22298810 PMID:34747641
Mglldecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MGLL mRNAPMID:21215274
Mgllmultiple interactionsEXP 6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MGLL mRNA]PMID:21215274
Mgllaffects expressionISOMgll (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MGLL mRNAPMID:24680724 PMID:26377647
Mglldecreases expressionISOMgll (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MGLL mRNAPMID:19465110
Mgllincreases expressionISOMgll (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MGLL mRNAPMID:18796159 PMID:19770486 PMID:25975270 PMID:26290441 PMID:28238261
Mgllmultiple interactionsISOMgll (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of MGLL mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of MGLL mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGLL mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of MGLL mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGLL mRNA]PMID:16054899 PMID:16214954 PMID:17942748 PMID:25975270 PMID:28433925
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