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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNAPMID:21215274
Akr1c3multiple interactionsEXP 6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNA]PMID:21215274
Akr1c3affects expressionISOAkr1c18 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AKR1C18 mRNAPMID:21570461
Akr1c3decreases expressionISOAKR1C3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNAPMID:19619570
Akr1c3increases expressionISOAkr1c18 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of AKR1C18 mRNAPMID:28922406
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AKR1C3 mRNAPMID:19619570
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