GENE - CHEMICAL INTERACTIONS REPORT
RGD ID:
69473
Species:
Homo sapiens
RGD Object:
Gene
Symbol:
SREBF1
Name:
sterol regulatory element binding transcription factor 1
Acc ID:
CHEBI:28119
Term:
2,3,7,8-tetrachlorodibenzodioxine
Definition:
A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
CasRN:
1746-01-6
Chemical ID:
MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
decreases expression EXP 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:20106945 decreases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:18295293 PMID:20005886 multiple interactions ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 mRNA] PMID:16054899 decreases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 protein PMID:20181658 decreases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:20005886 PMID:18295293 decreases expression ISO RGD:69423 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:21215274 increases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in increased expression of SREBF1 mRNA PMID:21846477 decreases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:18295293 PMID:20005886 PMID:21851831 multiple interactions ISO RGD:69474 6480464 CTD 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA] PMID:21851831 multiple interactions ISO RGD:69474 6480464 CTD NFE2L2 gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SREBF1 mRNA] PMID:21846477 decreases expression ISO RGD:69423 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:21215274 PMID:21724226 decreases expression ISO RGD:69474 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:18295293 PMID:20005886 PMID:21851831 PMID:23238561 decreases expression ISO RGD:69423 6480464 CTD Tetrachlorodibenzodioxin results in decreased expression of SREBF1 mRNA PMID:21215274 PMID:21724226 PMID:23238561 
