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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69250 Species: Rattus norvegicus RGD Object: Gene Symbol: Wnt5a Name: wingless-type MMTV integration site family, member 5A

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1353257	6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of WNT5A mRNA	PMID:19619570
decreases expression	ISO	RGD:1353257	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of WNT5A mRNA	PMID:20106945
increases expression	ISO	RGD:1353257	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of WNT5A mRNA	PMID:19619570
decreases expression	ISO	RGD:734385	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of WNT5A mRNA	PMID:17586704 PMID:19933214
decreases expression	ISO	RGD:734385	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of WNT5A mRNA	PMID:19933214 PMID:17586704
increases expression	ISO	RGD:1353257	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of WNT5A protein	PMID:21802500
increases expression	ISO	RGD:1353257	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of WNT5A mRNA	PMID:19619570 PMID:21802500 PMID:22262711