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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaa1a
Name: acetyl-CoA acyltransferase 1A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acaa1aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ACAA1 mRNA; Tetrachlorodibenzodioxin results in increased expression of ACAA1A mRNAPMID:16054898 PMID:16960034 PMID:33387578
Acaa1aaffects expressionISOAcaa1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ACAA1A mRNAPMID:21570461
Acaa1aincreases expressionISOAcaa1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ACAA1A mRNAPMID:16960034 PMID:19770486 PMID:28213091
Acaa1amultiple interactionsISOAcaa1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACAA1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACAA1A gene]PMID:28213091 PMID:28433925
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