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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620763 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyr61 Name: cysteine-rich, angiogenic inducer, 61

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731721	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYR61 mRNA	PMID:17942748
increases expression	ISO	RGD:731720	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYR61 mRNA	PMID:15056799 PMID:20106945
affects expression	ISO	RGD:731721	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of CYR61 mRNA	PMID:16611356
decreases expression	ISO	RGD:731721	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CYR61 mRNA	PMID:19770486
multiple interactions	ISO	RGD:731721	6480464	CTD	Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to CYR61 promoter]	PMID:19654925
increases expression	ISO	RGD:731720	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYR61 mRNA	PMID:20106945 PMID:15056799
affects expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin affects the expression of CYR61 mRNA	PMID:22298810
increases expression	ISO	RGD:731720	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYR61 mRNA	PMID:15056799 PMID:20106945 PMID:21632981
affects expression	ISO	RGD:731721	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of CYR61 mRNA	PMID:16611356 PMID:21570461
increases expression	ISO	RGD:731720	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYR61 mRNA	PMID:15056799 PMID:20106945 PMID:21496263 PMID:21632981
increases expression	ISO	RGD:731721	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of CYR61 mRNA	PMID:21496263