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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lmna
Name: lamin A/C
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lmnaaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of LMNA mRNAPMID:34747641
Lmnadecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of LMNA mRNA; Tetrachlorodibenzodioxin results in decreased expression of LMNA proteinPMID:11752688 PMID:19201780
Lmnaincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LMNA mRNAPMID:16960034
Lmnaaffects expressionISOLmna (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of LMNA mRNAPMID:21570461
Lmnaincreases expressionISOLmna (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LMNA mRNAPMID:16960034 PMID:17942748 PMID:19770486
Lmnamultiple interactionsISOLMNA (Homo sapiens)6480464CTDLMNA protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]PMID:12761348
Lmnamultiple interactionsISOLmna (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LMNA mRNAPMID:17942748
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