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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620446
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shc1
Name: SHC adaptor protein 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shc1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SHC1 mRNAPMID:34747641
Shc1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SHC1 mRNAPMID:33387578
Shc1multiple interactionsEXP 6480464CTDCBL protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]]]; Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]]PMID:9918770
Shc1affects expressionISOShc1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SHC1 mRNAPMID:21570461 PMID:24680724
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