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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp13decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MMP13 mRNAPMID:34747641
Mmp13increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP13PMID:17003102
Mmp13affects expressionISOMmp13 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MMP13 mRNAPMID:21570461 PMID:26377647
Mmp13decreases expressionISOMmp13 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MMP13 mRNAPMID:29673856
Mmp13increases expressionISOMMP13 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP13 mRNA; Tetrachlorodibenzodioxin results in increased expression of MMP13 proteinPMID:15531779 PMID:19684285
Mmp13increases expressionISOMmp13 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP13; Tetrachlorodibenzodioxin results in increased expression of MMP13 mRNAPMID:16120747 PMID:17003102 PMID:17975115 PMID:19372248 PMID:19684285 PMID:26290441 PMID:31270306
Mmp13multiple interactionsISOMMP13 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MMP13 mRNAPMID:19684285
Mmp13multiple interactionsISOMmp13 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MMP13 promoter]PMID:19654925
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