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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817 Species: Rattus norvegicus RGD Object: Gene Symbol: Col1a1 Name: collagen, type I, alpha 1

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:734049	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:20106945
multiple interactions	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin promotes the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]	PMID:18670907
affects expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of COL1A1 mRNA	PMID:20702594
multiple interactions	ISO	RGD:62109	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL1A1 mRNA	PMID:17942748
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:17942748 PMID:18670907 PMID:16611356 PMID:15328365
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:18670907 PMID:16611356 PMID:15328365 PMID:17942748
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:16611356 PMID:15328365 PMID:18670907 PMID:17942748
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:15328365 PMID:16611356 PMID:17942748 PMID:18670907
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:18670907 PMID:17942748 PMID:15328365 PMID:16611356
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:16611356 PMID:18670907 PMID:17942748 PMID:15328365
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:15328365 PMID:16611356 PMID:17942748 PMID:18670907 PMID:21846477
multiple interactions	ISO	RGD:62109	6480464	CTD	NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA]	PMID:21846477
affects expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of COL1A1 mRNA	PMID:20702594 PMID:21570461
affects expression	ISO	RGD:734049	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of COL1A1 mRNA	PMID:22574217
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:20959002
increases expression	ISO	RGD:62109	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of COL1A1 mRNA	PMID:15034205 PMID:15328365 PMID:16611356 PMID:17942748 PMID:18670907 PMID:21846477