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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SMAD2 mRNAPMID:34747641
Smad2affects expressionISOSmad2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SMAD2 mRNAPMID:21570461
Smad2affects phosphorylationISOSMAD2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the phosphorylation of SMAD2 proteinPMID:31887333
Smad2decreases expressionISOSmad2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SMAD2 protein; Tetrachlorodibenzodioxin results in decreased expression of SMAD2 protein modified formPMID:33812962
Smad2increases activityISOSmad2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased activity of SMAD2 proteinPMID:18467041
Smad2increases expressionISOSmad2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SMAD2 mRNA; Tetrachlorodibenzodioxin results in increased expression of SMAD2 proteinPMID:18467041 PMID:24058054
Smad2multiple interactionsISOSMAD2 (Homo sapiens)6480464CTDAHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD2 protein]PMID:31887333
Smad2multiple interactionsISOSmad2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA; [Tetrachlorodibenzodioxin results in increased expression of TGFB1 protein] which results in increased activity of SMAD2 proteinPMID:17942748 PMID:18467041
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