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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HNF4A mRNAPMID:20959002
Hnf4aaffects expressionISOHnf4a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of HNF4A mRNAPMID:21570461
Hnf4adecreases expressionISOHnf4a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of HNF4A mRNAPMID:29452137
Hnf4aincreases expressionISOHnf4a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of HNF4A mRNAPMID:19770486 PMID:24058054
Hnf4amultiple interactionsISOHnf4a (Mus musculus)6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HNF4A mRNA]PMID:29452137
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