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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2321145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxw7increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FBXW7 mRNAPMID:33387578
Fbxw7affects expressionISOFbxw7 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FBXW7 mRNAPMID:21570461 PMID:24058054
Fbxw7multiple interactionsISOFbxw7 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBXW7 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FBXW7 promoter]PMID:17942748 PMID:19654925
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