Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2023
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acp3
Name: acid phosphatase 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acp3affects expressionISOAcp3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ACP3 mRNAPMID:20702594 PMID:26377647
Acp3increases expressionISOAcp3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ACP3 mRNAPMID:17337447 PMID:18796159 PMID:19770486 PMID:19933214 PMID:20159946 PMID:26290441 PMID:31511937
Acp3multiple interactionsISOAcp3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ACP3 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ACP3 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACP3 promoter]PMID:16214954 PMID:17942748 PMID:19654925 PMID:25975270
Go Back to source page   Continue to Ontology report