Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of H2AX mRNAPMID:33387578
H2axaffects expressionISOH2ax (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of H2AX mRNAPMID:21570461
H2axincreases expressionISOH2ax (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of H2AX proteinPMID:21846477 PMID:33823233
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDNFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AX protein]; Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of H2AX protein]PMID:21846477
Go Back to source page   Continue to Ontology report