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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560577 Species: Rattus norvegicus RGD Object: Gene Symbol: Ormdl3 Name: ORM1-like 3 (S. cerevisiae)

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1558251	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ORMDL3 mRNA	PMID:17942748
multiple interactions	ISO	RGD:1558251	6480464	CTD	[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ORMDL3 mRNA	PMID:16214954
decreases expression	ISO	RGD:1558251	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of ORMDL3 mRNA	PMID:18796159
increases expression	ISO	RGD:1558251	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ORMDL3 mRNA	PMID:17942748
decreases expression	ISO	RGD:1558251	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of ORMDL3 mRNA	PMID:19770486 PMID:18796159
decreases expression	ISO	RGD:1558251	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of ORMDL3 mRNA	PMID:18796159 PMID:19770486
affects expression	ISO	RGD:1558251	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of ORMDL3 mRNA	PMID:21570461
increases expression	ISO	RGD:1352369	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ORMDL3 mRNA	PMID:21632981