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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smpd1
Name: sphingomyelin phosphodiesterase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smpd1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SMPD1 mRNAPMID:34747641
Smpd1affects expressionISOSmpd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SMPD1 mRNAPMID:21570461
Smpd1decreases activityISOSMPD1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased activity of SMPD1 proteinPMID:19131362
Smpd1increases expressionISOSMPD1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of SMPD1 mRNAPMID:23152189
Smpd1increases expressionISOSmpd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SMPD1 mRNAPMID:19770486
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