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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319717 Species: Homo sapiens RGD Object: Gene Symbol: POLR2I Name: polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1319718	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of POLR2I mRNA	PMID:19465110
decreases expression	ISO	RGD:1309395	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of POLR2I mRNA	PMID:21215274