• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317388 Species: Homo sapiens RGD Object: Gene Symbol: MMP1 Name: matrix metallopeptidase 1 (interstitial collagenase)

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA] AHR protein promotes the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]] alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA] Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA] alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]]	PMID:15075337
multiple interactions	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP1 protein	PMID:15982688
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1	PMID:17003102
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:20106945 PMID:18061397 PMID:15982688 PMID:19755661 PMID:15075337
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 protein	PMID:15531779
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:15075337 PMID:19755661 PMID:20106945 PMID:18061397 PMID:15982688 PMID:12377990
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:19755661 PMID:20106945 PMID:12377990 PMID:18061397 PMID:15982688 PMID:15075337
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:15075337 PMID:20106945 PMID:18061397 PMID:15982688 PMID:19755661
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:15982688 PMID:19755661 PMID:15075337 PMID:12377990 PMID:18061397 PMID:20106945
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:15982688 PMID:15075337 PMID:18061397 PMID:20106945 PMID:19755661
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:15075337 PMID:15982688 PMID:18061397 PMID:19755661 PMID:20106945
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:15075337 PMID:15982688 PMID:18061397 PMID:19755661 PMID:20106945 PMID:21632981
affects expression	ISO	RGD:1317389	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of MMP1A mRNA	PMID:21570461
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA	PMID:12377990 PMID:15075337 PMID:15982688 PMID:18061397 PMID:19755661 PMID:20106945 PMID:21632981 PMID:23152189