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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313700 Species: Mus musculus RGD Object: Gene Symbol: Dhrs3 Name: dehydrogenase/reductase (SDR family) member 3

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1313699	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:19619570 PMID:20106945
affects expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin affects the expression of DHRS3 mRNA	PMID:18343893
multiple interactions	ISO	RGD:1313699	6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DHRS3 mRNA	PMID:19619570
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:16611356 PMID:15800033 PMID:15328365
increases expression	ISO	RGD:1313699	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:20106945 PMID:19619570
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of DHRS3 mRNA	PMID:19770486
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:15328365 PMID:16611356 PMID:15800033
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:16611356 PMID:15328365 PMID:15800033
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:15800033 PMID:15328365 PMID:16611356
affects expression	ISO	RGD:1305584	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of DHRS3 mRNA	PMID:22298810
increases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of DHRS3 mRNA	PMID:15328365 PMID:15800033 PMID:16611356
decreases expression	ISO	RGD:1305584	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of DHRS3 mRNA	PMID:21215274
decreases expression	ISO	RGD:1305584	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of DHRS3 mRNA	PMID:21215274 PMID:21724226