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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309921 Species: Rattus norvegicus RGD Object: Gene Symbol: Tnnc1 Name: troponin C type 1 (slow)

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1320524	6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNNC1 mRNA]	PMID:11007951
increases expression	ISO	RGD:1320524	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of TNNC1 mRNA	PMID:20106945 PMID:11007951
increases expression	ISO	RGD:1320524	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of TNNC1 mRNA	PMID:11007951 PMID:20106945
decreases expression	ISO	RGD:1553347	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of TNNC1 mRNA	PMID:21354282
increases expression	ISO	RGD:1320524	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of TNNC1 mRNA	PMID:11007951 PMID:20106945 PMID:21632981
affects expression	ISO	RGD:1553347	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of TNNC1 mRNA	PMID:21570461