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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307751 Species: Rattus norvegicus RGD Object: Gene Symbol: Srebf2 Name: sterol regulatory element binding transcription factor 2

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:730973	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA	PMID:20005886
multiple interactions	ISO	RGD:730973	6480464	CTD	Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNA]	PMID:21851831
decreases expression	ISO	RGD:730973	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA	PMID:20005886 PMID:21851831
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA	PMID:21215274
affects expression	ISO	RGD:730973	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of SREBF2 mRNA	PMID:21570461