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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10322 Species: Mus musculus RGD Object: Gene Symbol: Cdkn2a Name: cyclin-dependent kinase inhibitor 2A

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:737039	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CDKN2A protein	PMID:17070097
decreases expression	ISO	RGD:737039	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CDKN2A mRNA	PMID:17070097 PMID:17257637
multiple interactions	EXP		6480464	CTD	[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A mRNA [Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of CDKN2A protein	PMID:21167638
decreases expression	ISO	RGD:737039	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of CDKN2A mRNA	PMID:17257637 PMID:17070097
affects expression	ISO	RGD:2323	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of CDKN2A mRNA	PMID:22298810