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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69192 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp27b1 Name: cytochrome P450, family 27, subfamily b, polypeptide 1

Acc ID: CHEBI:28088 Term: genistein Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. CasRN: 446-72-0 Chemical ID: MESH:D019833

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects activity	ISO	RGD:69201	6480464	CTD	Genistein affects the activity of CYP27B1 protein	PMID:17659868
affects expression	ISO	RGD:69201	6480464	CTD	Genistein affects the expression of CYP27B1 mRNA	PMID:17659868
increases activity	ISO	RGD:69201	6480464	CTD	Genistein results in increased activity of CYP27B1 protein	PMID:15795327
increases expression	ISO	RGD:69201	6480464	CTD	Genistein results in increased expression of CYP27B1 mRNA	PMID:15795327