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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp27b1affects activityISOCYP27B1 (Homo sapiens)6480464CTDGenistein affects the activity of CYP27B1 proteinPMID:17659868
Cyp27b1affects expressionISOCYP27B1 (Homo sapiens)6480464CTDGenistein affects the expression of CYP27B1 mRNAPMID:17659868
Cyp27b1increases activityISOCYP27B1 (Homo sapiens)6480464CTDGenistein results in increased activity of CYP27B1 proteinPMID:15795327
Cyp27b1increases expressionISOCYP27B1 (Homo sapiens)6480464CTDGenistein results in increased expression of CYP27B1 mRNAPMID:15795327
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