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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115 Species: Homo sapiens RGD Object: Gene Symbol: CDKN1B Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Acc ID: CHEBI:28088 Term: genistein Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. CasRN: 446-72-0 Chemical ID: MESH:D019833

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Genistein results in increased expression of CDKN1B protein	PMID:15829497
increases expression	ISO	RGD:69116	6480464	CTD	Genistein results in increased expression of CDKN1B mRNA	PMID:21048042