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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1decreases activityISOUGT1A1 (Homo sapiens)6480464CTDGenistein results in decreased activity of UGT1A1 proteinPMID:16051636
Ugt1a1decreases expressionISOUGT1A1 (Homo sapiens)6480464CTDGenistein results in decreased expression of UGT1A1 mRNA; Genistein results in decreased expression of UGT1A1 proteinPMID:18634814
Ugt1a1increases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased glucuronidation of GenisteinPMID:14557274 PMID:15988124
Ugt1a1multiple interactionsISOUgt1a1 (Mus musculus)6480464CTDGenistein inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]PMID:23333575
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