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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionISOStat3 (Mus musculus)6480464CTDGenistein results in decreased expression of STAT3 mRNAPMID:21048042
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDGenistein results in decreased expression of STAT3 mRNAPMID:20816778
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDGenistein results in increased expression of STAT3 mRNAPMID:15289156
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDGenistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; Genistein inhibits the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]PMID:10364193 PMID:33396024
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