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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases expressionEXP 6480464CTDGenistein results in increased expression of EGFR proteinPMID:15781664
Egfrmultiple interactionsEXP 6480464CTD[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Genistein results in increased secretion of Testosterone]PMID:19059320
Egfrdecreases expressionISOEgfr (Mus musculus)6480464CTDGenistein results in decreased expression of EGFR mRNAPMID:11880592
Egfrdecreases expressionISOEGFR (Homo sapiens)6480464CTDGenistein results in decreased expression of EGFR mRNAPMID:15257099
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD[Genistein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Genistein co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Genistein co-treated with ESR2 protein] results in decreased expression of EGFR mRNA; [Genistein co-treated with ESR2 protein] results in decreased expression of EGFR proteinPMID:19347870
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