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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2462
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp24a1multiple interactionsEXP 6480464CTD[Genistein co-treated with vinclozolin] results in increased expression of CYP24A1 mRNAPMID:23160963
Cyp24a1decreases activityISOCYP24A1 (Homo sapiens)6480464CTDGenistein results in decreased activity of CYP24A1 proteinPMID:15955619
Cyp24a1multiple interactionsISOCYP24A1 (Homo sapiens)6480464CTDGenistein inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]; Genistein inhibits the reaction [CYP24A1 protein results in increased degradation of Calcitriol]; Genistein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]PMID:15955619
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