RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69057
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Nr1i2
Name:	nuclear receptor subfamily 1, group I, member 2

Acc ID:	CHEBI:28077
Term:	rifampicin
Definition:	A rifamycin that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
CasRN:	13292-46-1
Chemical ID:	MESH:D012293

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:69106	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:18692084
multiple interactions	ISO	RGD:69105	6480464	CTD	Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]] NR1I2 protein affects the reaction [Rifampin results in increased expression of and results in increased activity of CYP2B6 protein]	PMID:12695351
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP2C9 mRNA]	PMID:14600250
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	PMID:12695340
affects response to substance	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the susceptibility to Rifampin	PMID:15670600
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein promotes the reaction [Rifampin results in increased abundance of Lipids]	PMID:20079722
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:15864135 PMID:15849716 PMID:20041327 PMID:15933212 PMID:14977870 PMID:15883047 PMID:15630458
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]	PMID:20041327
affects binding	ISO	RGD:69105	6480464	CTD	Rifampin binds to NR1I2 protein	PMID:15705662
affects binding	ISO	RGD:69105	6480464	CTD	[Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoter	PMID:15933212
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA	PMID:18098064
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein] Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]	PMID:11581012
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein binds to CYP24A1 promoter]	PMID:15630458
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein binds to CYP2A6 promoter]	PMID:16857725
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]	PMID:17088262
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]	PMID:12417264
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]	PMID:16632523
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:21227907 PMID:19249324 PMID:15802384 PMID:16565514 PMID:16267138 PMID:12417264 PMID:15548381 PMID:15833926 PMID:12065438 PMID:14636322 PMID:18692084 PMID:15885729
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP2B6 mRNA [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA	PMID:17041008
multiple interactions	ISO	RGD:69105	6480464	CTD	sodium arsenite inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]	PMID:15833926
multiple interactions	ISO	RGD:69105	6480464	CTD	[fexofenadine co-treated with Rifampin] results in increased activity of NR1I2 protein [Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein	PMID:20869355
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	PMID:21742782 PMID:12695340
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:15883047 PMID:20041327 PMID:15849716 PMID:21742782 PMID:15630458 PMID:14977870 PMID:15864135 PMID:15933212
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:15802384 PMID:12065438 PMID:14636322 PMID:15833926 PMID:15885729 PMID:21227907 PMID:16267138 PMID:19249324 PMID:15548381 PMID:18692084 PMID:12417264 PMID:16565514
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	PMID:12695340 PMID:21742782
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:15883047 PMID:15864135 PMID:21115097 PMID:15849716 PMID:21742782 PMID:20041327 PMID:15630458 PMID:15933212 PMID:14977870
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin inhibits the reaction [NCOR1 protein binds to and results in decreased activity of NR1I2 protein] Rifampin inhibits the reaction [NCOR2 protein binds to and results in decreased activity of NR1I2 protein] Rifampin promotes the reaction [MED1 protein binds to and results in increased activity of NR1I2 protein] Rifampin promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]	PMID:22214767
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:15548381 PMID:18692084 PMID:15833926 PMID:14636322 PMID:21227907 PMID:22214767 PMID:16267138 PMID:15885729 PMID:15802384 PMID:19249324 PMID:12065438 PMID:16565514 PMID:12417264
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:15864135 PMID:15883047 PMID:21115097 PMID:15933212 PMID:14977870 PMID:21742782 PMID:20041327 PMID:15630458 PMID:15849716
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:21227907 PMID:18692084 PMID:15885729 PMID:15802384 PMID:16267138 PMID:14636322 PMID:19249324 PMID:12065438 PMID:12417264 PMID:15548381 PMID:16565514 PMID:15833926 PMID:22214767
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:20143881 PMID:19249324 PMID:16565514 PMID:21227907 PMID:15885729 PMID:12065438 PMID:15833926 PMID:15802384 PMID:22214767 PMID:16267138 PMID:18692084 PMID:12417264 PMID:15548381 PMID:14636322
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:14977870 PMID:20041327 PMID:15864135 PMID:15883047 PMID:21742782 PMID:15849716 PMID:21115097 PMID:15933212 PMID:15630458
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:15548381 PMID:19249324 PMID:12065438 PMID:15833926 PMID:14636322 PMID:18692084 PMID:16267138 PMID:21227907 PMID:20143881 PMID:15885729 PMID:22214767 PMID:19647009 PMID:12417264 PMID:16565514 PMID:15802384
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:15630458 PMID:15933212 PMID:21742782 PMID:15864135 PMID:15883047 PMID:15849716 PMID:14977870 PMID:21115097 PMID:20041327
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin binds to and results in increased activity of NR1I2 protein	PMID:14977870 PMID:15630458 PMID:15849716 PMID:15864135 PMID:15883047 PMID:15933212 PMID:20041327 PMID:21115097 PMID:21742782
affects binding	ISO	RGD:69105	6480464	CTD	Rifampin binds to NR1I2 protein	PMID:15705662 PMID:22314385
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA	PMID:20361990
multiple interactions	ISO	RGD:69105	6480464	CTD	Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]	PMID:21402137
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	PMID:12695340 PMID:21742782 PMID:22314385
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]	PMID:21115105
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]	PMID:21641981
multiple interactions	ISO	RGD:69105	6480464	CTD	7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein] 1,5-benzothiazepine analog promotes the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein] PK 11195 inhibits the reaction [[Rifampin co-treated with RXRA] results in increased activity of NR1I2 protein]	PMID:21315811
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21227907 PMID:21402137 PMID:21641981 PMID:22214767
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]	PMID:12417264 PMID:21402137
multiple interactions	ISO	RGD:69106	6480464	CTD	NR1I2 affects the reaction [Rifampin results in increased activity of CYP3A4 protein]	PMID:20361990
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin results in increased activity of NR1I2 protein] which results in increased expression of DHCR24 mRNA	PMID:22101211
affects binding	ISO	RGD:69106	6480464	CTD	Rifampin binds to NR1I2 gene mutant form	PMID:22467028
increases expression	ISO	RGD:69105	6480464	CTD	Rifampin results in increased expression of NR1I2 mRNA	PMID:22310298
multiple interactions	ISO	RGD:69106	6480464	CTD	[Rifampin binds to NR1I2 gene mutant form] which results in increased expression of CES2A mRNA [Rifampin binds to NR1I2 gene mutant form] which results in increased expression of CYP3A11 mRNA	PMID:22467028
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21227907 PMID:21402137 PMID:21641981 PMID:22101211 PMID:22214767
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A23/3A1 mRNA]	PMID:17483497
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA	PMID:17041008 PMID:21127053
multiple interactions	ISO	RGD:69105	6480464	CTD	NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]] Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA] Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP2C9 mRNA]	PMID:21292004
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA] NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP24A1 mRNA] NR1I2 protein promotes the reaction [Rifampin results in increased expression of GADD45B mRNA] [Rifampin co-treated with NR1I2 protein] results in decreased expression of CYP8B1 mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of HDAC5 mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of FOXA1 mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of GATA5 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of SERPINA4 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of AQP3 mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of HNF4A mRNA [Rifampin co-treated with NR1I2 protein] results in decreased expression of STAT5A mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of BHLHB2 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of BMP4 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR6 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP26A1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR7 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CDKN2B mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2S1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR4 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR2 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of CYR61 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of FIGF mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of HEY1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP3 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP4 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of HIF1A mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of HBEGF mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of JUN mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF5 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF6 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of LEFTY1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF2 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of NPAS1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of NPPB mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of MAFF mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of PIP4K2A mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINE1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB9 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB8 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB1 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SMAD9 mRNA [Rifampin co-treated with NR1I2 protein] results in increased expression of SOCS3 mRNA	PMID:21127053
multiple interactions	ISO	RGD:69105	6480464	CTD	[NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA [NR1I2 protein co-treated with Rifampin] results in decreased expression of SULT1E1 mRNA Rifampin promotes the reaction [NR1I2 protein binds to HNF4A protein] [Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]	PMID:21764778
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein promotes the reaction [Rifampin results in increased expression of CES2 mRNA]	PMID:17003103
multiple interactions	ISO	RGD:69105	6480464	CTD	NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	PMID:17003103 PMID:21127053
multiple interactions	ISO	RGD:69105	6480464	CTD	Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]	PMID:12417264 PMID:21292004 PMID:21402137
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:17003103 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21127053 PMID:21227907 PMID:21402137 PMID:21641981 PMID:22101211 PMID:22214767
increases activity	EXP		6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:17003103
multiple interactions	EXP		6480464	CTD	[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23/3A1 mRNA sodium arsenite inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23/3A1 mRNA]	PMID:22310326
increases expression	ISO	RGD:69105	6480464	CTD	Rifampin results in increased expression of NR1I2 mRNA	PMID:22310298 PMID:22664347
multiple interactions	EXP		6480464	CTD	arsenite inhibits the reaction [Rifampin results in increased localization of NR1I2 protein]	PMID:22159698
increases localization	EXP		6480464	CTD	Rifampin results in increased localization of NR1I2 protein	PMID:22159698
increases expression	ISO	RGD:69105	6480464	CTD	Rifampin results in increased expression of NR1I2 protein	PMID:22733800
multiple interactions	ISO	RGD:69105	6480464	CTD	[Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein	PMID:22733800
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:17003103 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21127053 PMID:21227907 PMID:21402137 PMID:21641981 PMID:22101211 PMID:22214767 PMID:22982774
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:17003103 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21127053 PMID:21227907 PMID:21402137 PMID:21641981 PMID:22101211 PMID:22206814 PMID:22214767 PMID:22982774
increases activity	ISO	RGD:69105	6480464	CTD	Rifampin results in increased activity of NR1I2 protein	PMID:12065438 PMID:12417264 PMID:14636322 PMID:15548381 PMID:15802384 PMID:15833926 PMID:15885729 PMID:16267138 PMID:16565514 PMID:17003103 PMID:18692084 PMID:19249324 PMID:19647009 PMID:20143881 PMID:21127053 PMID:21227907 PMID:21402137 PMID:21641981 PMID:21924250 PMID:22101211 PMID:22206814 PMID:22214767 PMID:22982774

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