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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2435 Species: Rattus norvegicus RGD Object: Gene Symbol: Cstb Name: cystatin B (stefin B)

Acc ID: CHEBI:28001 Term: vancomycin Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile. CasRN: 1404-90-6 Chemical ID: MESH:D014640

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10417	6480464	CTD	Vancomycin results in decreased expression of CSTB mRNA	PMID:18930951