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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:27999
Term: tolbutamide
Definition: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Chemical ID: MESH:D014044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6increases hydroxylationISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased hydroxylation of TolbutamidePMID:30500380
Cyp2c6increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased metabolism of TolbutamidePMID:18511451
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTD[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamidePMID:30500380
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