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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcaffects expressionEXP 6480464CTDCocaine affects the expression of SRC mRNAPMID:20187946
Srcdecreases activityISOSrc (Mus musculus)6480464CTDCocaine results in decreased activity of SRC proteinPMID:27506785
Srcincreases phosphorylationISOSrc (Mus musculus)6480464CTDCocaine results in increased phosphorylation of SRC proteinPMID:20354174
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