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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61862
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria2
Name: glutamate ionotropic receptor AMPA type subunit 2
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria2affects expressionEXP 6480464CTDCocaine affects the expression of GRIA2 mRNA; Cocaine affects the expression of GRIA2 proteinPMID:12511956 PMID:12787079 PMID:15140200 PMID:19105975 PMID:20187946 PMID:20534846
Gria2decreases response to substanceEXP 6480464CTDGRIA2 results in decreased susceptibility to CocainePMID:12511956
Gria2multiple interactionsEXP 6480464CTDCocaine results in increased phosphorylation of and affects the localization of GRIA2 proteinPMID:18945913
Gria2increases expressionISOGria2 (Mus musculus)6480464CTDCocaine results in increased expression of GRIA2 mRNAPMID:9886066
Gria2increases expressionISOGRIA2 (Homo sapiens)6480464CTDCocaine results in increased expression of GRIA2 proteinPMID:16363995
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