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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2652
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1increases expressionEXP 6480464CTDCocaine results in increased expression of GAD1 proteinPMID:15295023 PMID:18611417
Gad1decreases expressionISOGAD1 (Homo sapiens)6480464CTDCocaine results in decreased expression of GAD1 mRNAPMID:12629581
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