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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331975 Species: Mus musculus RGD Object: Gene Symbol: Pomc Name: pro-opiomelanocortin-alpha

Acc ID: CHEBI:27958 Term: cocaine Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. CasRN: 50-36-2 Chemical ID: MESH:D003042

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:3366	6480464	CTD	Cocaine results in increased expression of POMC protein	PMID:9610951 PMID:17001283
increases secretion	ISO	RGD:1352097	6480464	CTD	Cocaine results in increased secretion of POMC protein	PMID:11750770
increases response to substance	EXP		6480464	CTD	POMC results in increased susceptibility to Cocaine	PMID:18176854
multiple interactions	ISO	RGD:3366	6480464	CTD	[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]	PMID:19279569
increases response to substance	ISO	RGD:3366	6480464	CTD	POMC results in increased susceptibility to Cocaine	PMID:19279569
multiple interactions	ISO	RGD:3366	6480464	CTD	eticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein]	PMID:17001283
increases expression	ISO	RGD:3366	6480464	CTD	Cocaine results in increased expression of POMC protein alternative form	PMID:8301594
increases expression	ISO	RGD:3366	6480464	CTD	Cocaine results in increased expression of POMC protein	PMID:17001283 PMID:9610951