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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:27928
Term: parathion
Definition: An organothiophosphate insecticide that has formula C10H14NO5PS.
Chemical ID: MESH:D010278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects activityISOTP53 (Homo sapiens)6480464CTDParathion metabolite affects the activity of TP53 proteinPMID:35435491
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDParathion results in increased expression of TP53 protein; Parathion results in increased expression of TP53 protein mutant formPMID:12762645 PMID:17390078 PMID:17622325 PMID:19787260
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Parathion co-treated with Estradiol] results in increased expression of TP53 protein mutant form; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]PMID:12762645 PMID:17622325
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