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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:27902
Term: tetracycline
Definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
Chemical ID: MESH:D013752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp13decreases activityISOMMP13 (Homo sapiens)6480464CTDTetracycline analog results in decreased activity of MMP13 proteinPMID:17267227
Mmp13multiple interactionsISOMMP13 (Homo sapiens)6480464CTDTetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]PMID:17267227
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