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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertdecreases expressionISOTERT (Homo sapiens)6480464CTDCisplatin results in decreased expression of TERT mRNAPMID:17923759 PMID:27594783
Tertdecreases expressionISOTert (Mus musculus)6480464CTDCisplatin results in decreased expression of TERT mRNAPMID:24571982
Tertincreases response to substanceISOTERT (Homo sapiens)6480464CTDTERT protein mutant form results in increased susceptibility to CisplatinPMID:12488552
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in decreased activity of TERT protein; [decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Cisplatin; Cisplatin results in increased expression of and results in decreased activity of TERT proteinPMID:16082193 PMID:17923759 PMID:18021753
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