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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1affects expressionEXP 6480464CTDCisplatin affects the expression of SPP1 mRNAPMID:20623750
Spp1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of SPP1 mRNAPMID:22023808
Spp1increases expressionEXP 6480464CTDCisplatin results in increased expression of SPP1 mRNA; Cisplatin results in increased expression of SPP1 proteinPMID:11231351 PMID:15033597 PMID:18289764 PMID:22581811
Spp1increases secretionEXP 6480464CTDCisplatin results in increased secretion of SPP1 proteinPMID:28885000
Spp1affects expressionISOSpp1 (Mus musculus)6480464CTDCisplatin affects the expression of SPP1 mRNAPMID:21151649
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of SPP1 mRNAPMID:11099651
Spp1multiple interactionsISOSPP1 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of SPP1 mRNAPMID:27392435
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