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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of PPARG mRNA; Cisplatin results in decreased expression of PPARG proteinPMID:22989705 PMID:31103702 PMID:33522649 PMID:36228751
Ppargmultiple interactionsEXP 6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]; Rosiglitazone inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]; wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein]PMID:22989705 PMID:31103702 PMID:33522649 PMID:36228751
Ppargaffects activityISOPPARG (Homo sapiens)6480464CTDCisplatin affects the activity of PPARG proteinPMID:25596134
Ppargaffects expressionISOPPARG (Homo sapiens)6480464CTDCisplatin affects the expression of PPARG mRNAPMID:23300844
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDCisplatin results in decreased expression of PPARG proteinPMID:27417252
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[rosiglitazone binds to and results in increased activity of PPARG protein] which results in decreased susceptibility to Cisplatin; [rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased susceptibility to Cisplatin; PPARG protein results in increased susceptibility to [rosiglitazone co-treated with Cisplatin]PMID:21781307 PMID:27417252
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