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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1decreases response to substanceEXP 6480464CTDABCC1 protein results in decreased susceptibility to CisplatinPMID:11455017
Abcc1affects response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 affects the susceptibility to CisplatinPMID:15756446
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 mRNA results in decreased susceptibility to Cisplatin; ABCC1 protein results in decreased susceptibility to CisplatinPMID:15448748 PMID:21783896
Abcc1increases expressionISOAbcc1 (Mus musculus)6480464CTDCisplatin results in increased expression of ABCC1 proteinPMID:25043994
Abcc1multiple interactionsISOAbcc1 (Mus musculus)6480464CTDChlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein]PMID:25043994
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCC1 mRNA; [Estradiol results in increased expression of ABCC1 mRNA] which results in increased susceptibility to Cisplatin; [Proadifen co-treated with Cisplatin] results in decreased expression of ABCC1 protein; [PTGS2 protein results in increased expression of ABCC1 protein] which results in increased susceptibility to Cisplatin; ABCC1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]PMID:18695918 PMID:21964646 PMID:26721606 PMID:28323900 PMID:32800223
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