Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2543
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Egfr
Name:	epidermal growth factor receptor

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Egfr	affects response to substance	ISO	EGFR (Homo sapiens)	6480464	CTD	EGFR protein affects the susceptibility to Cisplatin	PMID:21431282
Egfr	decreases response to substance	ISO	EGFR (Homo sapiens)	6480464	CTD	EGFR mRNA results in decreased susceptibility to Cisplatin; EGFR results in decreased susceptibility to Cisplatin	PMID:18337622 PMID:21849418 PMID:21909139
Egfr	increases phosphorylation	ISO	EGFR (Homo sapiens)	6480464	CTD	Cisplatin results in increased phosphorylation of EGFR protein	PMID:20726858
Egfr	increases response to substance	ISO	EGFR (Homo sapiens)	6480464	CTD	EGFR protein results in increased susceptibility to Cisplatin	PMID:21324906
Egfr	multiple interactions	ISO	Egfr (Mus musculus)	6480464	CTD	Cisplatin promotes the reaction [PRKDC protein binds to EGFR protein]	PMID:21266349
Egfr	multiple interactions	ISO	EGFR (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with Fluorouracil] results in decreased expression of EGFR mRNA; [Cisplatin co-treated with Quercetin] results in increased expression of EGFR mRNA; [ITGB1 protein results in increased activity of EGFR protein] which results in decreased susceptibility to Cisplatin; [TNFSF10 protein co-treated with Cisplatin] results in decreased expression of EGFR protein; Cisplatin promotes the reaction [HER3 protein binds to EGFR protein]; Cisplatin results in increased phosphorylation of and results in increased uptake of EGFR protein; EGFR gene mutant form results in increased susceptibility to [Gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; EGFR results in increased susceptibility to [Cisplatin co-treated with Docetaxel co-treated with Fluorouracil]; LRIG1 protein inhibits the reaction [Cisplatin results in increased phosphorylation of and affects the localization of EGFR protein]	PMID:15737843 PMID:20726858 PMID:21252285 PMID:21431282 PMID:21478906 PMID:21541241 PMID:21947696 PMID:27514524

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